隨著近年來快速的工業化與都市化，人們的生活雖日趨安逸，但許多文明帶來的挑戰亦隨之浮現，例如:環境污染、能源耗竭、以及傳染性疾病。本實驗室之研究方向為分子生物技術於能源、環境及醫學上之應用，目前主要的研究重點如下:
1、  生物啟發工程(Bioinspired Engineering)於酵素合成之調控機制上的應用並將其運用推廣至生質能源上。
2、  以蛋白質模組(Protein Module)回收高科技產業廢水中之貴重金屬或稀有元素。
3、  利用合成生物學(Synthetic Biology)技術來發展可自動搜尋汙染源並將目標汙染物分解(seek and destroy)之聰明細菌(smart microbes)。
4、  開發新型生物感測器(Biosensor)及其於環境及醫學上之應用。
5、  高通量(High-throughput)抗菌?(anti-microbial peptide)篩選技術之開發與運用。

11    1.Shen-Long Tsai, Chi-Wen Lin*, Chih-Hung Wu, and Chih-Min Shen, Kinetics of xenobiotic biodegradation for Pseudomonas sp. YATO411 strain in suspension and cell-immobilized beads, submitted, 2012.
 2.Shen-Long Tsai, Fang Liu, Qing Sun, Heejea Kim, and Wilfred Chen*, Nanobiocatalysis and its potential applications, submitted, 2012.
 3.Shen-Long Tsai, Miso Park and Wilfred Chen*, Effect of particle size on cellulase clustering and cellulose hydrolysis, Biotechnology Journal, Accepted, 2012.
 4.Shen-Long Tsai, Nancy A DaSilva and Wilfred Chen*, Functional display of complex cellulosomes on the yeast cell surface for enhanced cellulosic ethanol production, ACS Synthetic Biology, Accepted, 2012.
 5.Fang Liu, Shen-Long Tsai, Bhawna Madan, and Wilfred Chen*, Engineering a high-affinity scaffold for the non-chromatographic protein purification via intein-mediated cleavage, Biotechnol Bioeng, Accepted, 2012. 
 6.Shen-Long Tsai, Chi-Wen Lin*, and Chih-Hung Wu, Cell immobilization technique for biotrickle filtering of isopropyl alcohol waste gas generated by high-technology industries, Journal of Chemical Technology and Biotechnology, accepted, 2012.
 7.Shen-Long Tsai, Shailendra Singh, Nancy A DaSilva, and Wilfred Chen*, Coexpression ofArabidopsis thaliana phytochelatin synthase and Treponema denticola cystalysin leads to enhanced arsenic accumulation, Biotechnol Bioeng, 2012. 109, 605-608
 8.Garima Goyal, Shen-Long Tsai, Bhawna Madan, Nancy A DaSilva, and Wilfred Chen*, Engineering synthetic consortia for consolidated bioprocessing, Microbial Cell Factories, 2011.10:89
9. Shen-Long Tsai, Garima Goyal, and Wilfred Chen*, Surface display of a functional mini-cellulosome by intracellular complementation using a synthetic yeast consortium: Application for cellulose hydrolysis and ethanol production, Appl Environ Microbiol, 76, 7514–7520, 2010.
10.Shen-Long Tsai, Shailendra Singh, and Wilfred Chen*, Arsenic metabolism by microbes in nature and the impact on arsenic remediation, Curr Opin Biotechnol, 20, 659–667, 2009.
11.Shen-Long Tsai, Jeongseok Oh, Shailendra Singh, Ruizhen Chen, and Wilfred Chen*, Functional assembly of mini-cellulosomes on the yeast surface for cellulose hydrolysis and ethanol production, Appl Environ Microbiol, 75, 6087-6093, 2009.