教授課程

1.微積分[Calculus(Ⅰ)]
2.循環生理訊號學
3.生醫資訊處理[Biomedical Signal Process]

榮譽獎項

指導大學專題生得獎
(1) 元智大學工學院大學部 94年度論文比賽特優(程健銘、王敬懿、許家良、何國廷)：結合溫度壓力控制紅外光血壓波形量測系統之架設與初步測試
(2) 元智大學工學院大學部 95年度論文比賽優等(詹千蓁、王韻茹)：微循環生理狀態評估系統之加熱效應研究

期刊論文

1. Hsin Hsiu, Chia-Liang Hsu, Ming-Yie Jan. Relations between beat-to-beat
microcirculatory blood flow and variations therein. Photomed Laser Surg, accepted (SCI,
IF=1.785, 53/148, Surgery).
2. Hsin Hsiu, Wei-Chen Hsu, Chia-Liang Hsu, Shih-Ming Huang. Assessing the effects of
acupuncture by comparing needling the Hegu acupoint and needling nearby
nonacupoints by spectral analysis of microcirculatory laser Doppler signals. Accepted,
Evid Based Complement Alternat Med. (SCI, IF=1.954, 5/14, Integrative and
Complementary Medicine).
3. Hsin Hsiu, Wei-Chen Hsu, Bo-Hung Chen, Chia-Liang Hsu. Different microcirculatory
effects between acupuncture point and non-acupoint by applying local skin-surface
contacting pressure stimulation – possible relevance with acupressure. Physiol. Meas. 31
(2010) 829-841 (SCI, IF=1.691, 27/51, Biomedical Engineering)
4. Hsin Hsiu, Wei-Chen Hsu, Chia-Liang Hsu, Shih-Ming Huang, Yuh-Ying Lin Wang.
Microcirculatory changes by laser Doppler after infra-red heating over acupuncture
points – relevance to moxibustion. Photomed Laser Surg 27(6): 855-61, 2009. (SCI,
IF=1.785, 53/148, Surgery)
5. Hsin Hsiu, Wei-Chen Hsu, Chia-Liang Hsu, Ming-Yie Jan, Yuh-Ying Lin Wang.
Effects of acupuncture at the Hoku acupoint on the pulsatile laser Doppler signal at the
heartbeat frequency. Laser Med Sci, 24(4): 553-560, 2009. (SCI, IF=1.675, 57/148,
Surgey)
6. Hsiu H, Hsu WC, Huang SM, Hsu CL, Wang Lin YY. Spectral analysis of the
microcirculatory laser Doppler signal at the Hoku acupuncture point. Laser Med Sci
24(3): 353-358, 2009. (SCI, IF=1.675, 57/148, Surgey).
7. Hsin Hsiu, Wei-Chen Hsu, Shu-Ling Chang, Chia-Liang Hsu, Shih-Ming Huang,
Yuh-Ying Lin Wang. Microcirculatory effect of different skin contacting pressures
around the blood pressure. Physiol. Meas. 29: 1421-1434, 2008. (SCI, IF=1.691, 27/51,
Biomedical Engineering)
8. Hsiu H, Hsu CL, Chiang WR, Chao PT, Hsu TL, Jan MY, Wang WK, Wang Lin YY.
Connection between RR-interval length and the pulsatile microcirculatory flow. Physiol.
Meas, 29: 245-254, 2008. (SCI, IF=1.691, 27/51, Biomedical Engineering).
9. Hsiu H, Chao PT., Hsu, WC, Jan MY, Wang Lin YY & Wang WK. The possible role of
arterial radial vibration in heart rate and blood pressure matching. P I Mech Eng H,
Journal of Engineering in Medicine, 222(H5), 773-779, 2008. (SCI, IF=1.402, 37/106,
Mechanical Engineering).
10. Hsiu, H., Huang SM, Chao PT, Jan MY, Hsu TL, Wang WK & Wang Lin YY.
Microcirculatory characteristics of acupuncture points obtained by laser Doppler
flowmetry. Physiol. Meas., 28 (2007) N77-N86. (SCI, IF=1.691, 27/51, Biomedical
Engineering).
11. Hsin H, PT Chao, WR Chiang, CL Hsu, MY Jan, WK Wang, YY Lin Wang. Effect of
pulse number on the pulse-based synchronized-averaging analysis in laser Doppler signal.
Biomedical Engineering — Application, Basis & Communication; 19(3): 179-185, 2007.
(EI)
12. Hsiu, H., M.Y. Jan, W.K. Wang & Y.Y. Lin Wang. Effects of double-HR-frequency
mechanical stimulation on blood pressure waveform of rats. Physiol. Meas., 27 (2006)
131-144. (SCI, IF=1.691, 27/51, Biomedical Engineering)
13. Chao PT, Jan MY, Hsiu H, Hsu TL, Wang WK & Wang Lin YY. Evaluating
microcirculation by pulsatile laser Doppler signal. Phys. Med. Biol., 51: 845-854, 2006.
(SCI, IF=2.784, 9/51, Biomedical Engineering)
14. Hsu TL, Chao PT, Hsiu H, Wang WK, Li SP & Wang Lin YY. Organ-specific
ligation-induced changes in harmonic components of the pulse spectrum and regional
vasoconstrictor selectivity in Wistar rats. Exp. Physiol., 91.1: 163–170, 2006. (SCI,
IF=2.339, 33/79)
15. Hsu TL, Hsiu H, Chao PT, Li SP, Wang WK & Wang Lin YY. Three-block electrical
model of renal impedance. Physiol. Meas. 26: 387-399. 2005. (SCI, IF=1.691, 27/51,
Biomedical Engineering)
16. YC Kuo, SH Lo, PT Chao, H Hsiu, WK Wang, YY Lin Wang. Raising harmonic
variation of arterial pulse during the dying process in rats. Am. J. Chin. Med. 33(1):
73-85, 2005 (SCI, IF=1.058, 69/103, General Medicine).
17. H. Hsiu, PT Chao, TL Hsu, WC Hsu, WK Wang. Effects of weak external mechanical
force stimulation on the heart rate variability of rats. Biomedical Engineering —
Application, Basis & Communications, 16(6): 20-28, 2004 (EI).
18. H. Hsiu, M.Y. Jan, Y.Y. Lin Wang, W.K. Wang. Effects of aorta bending and renal
ligation on the blood pressure: a simulation on arterial stiffening. Biomedical
Engineering — Application, Basis & Communications, 15(6): 32-37, 2003 (EI).
19. Hsiu, H., Jan, M. Y., Wang Lin, Y. Y. & Wang, W. K. Influencing the heart rate of rats
with weak external mechanical stimulation. PACE 26: 36-43, 2003. (SCI, IF=1.59, 32/51,
Biomedical Engineering)
20. Jan, M. Y., Hsiu, H., Hsu, T. L., Wang, W. K. & Wang Lin, Y. Y. The physical
conditions of different organs are reflected in the pressure pulse spectrum of the
peripheral artery specifically. J. of Cardiovascular engineering 3(1):21-29, 2003. (EI)
21. Hsiu, H., Luo, K. J., Wang Lin, Y. Y. & Wang, W. K. Semi-empirical resonance
equations for the artery with organs. Biomedical Engineering — Application, Basis &
Communications 12(1): p1-9, 2000. (EI)
22. Jan, M. Y., Hsiu, H., Hsu, T. L., Wang Lin, Y. Y. & Wang, W. K. Measurement and
analysis of the pulsatile renal cortical fluxes in rats with a fast laser Doppler flowmetry.
Biomedical Engineering — Application, Basis & Communications 12(2): p1-6, 2000.
(EI)
23. Jan, M. Y., Hsiu, H., Hsu, T. L., Wang Lin, Y. Y. & Wang, W. K. The importance of the pulsatile microcirculation in relation to hypertension. IEEE Eng. Med. Biol., 19(3):
p106-111, 2000. (SCI)
24. Wang Lin, Y. Y., Lia, W. C., Hsiu, H., Jan, M. Y. & Wang, W. K. Effect of length on
the fundamental resonance frequency of arterial models having radial dilatation. IEEE
Trans. Bio-Med. Eng. 47: p313-318, 2000. (SCI)
25. Wang Lin, Y. Y., Chang, C. C, Chen, J. C., Hsiu, H. & Wang, W. K. Pressure wave
propagation in arteries. IEEE. Eng. Med. Biol., 16: p51-56, 1997. (SCI)

研討會論文

c1. Hsin Hsiu, Chia-Liang Hsu, Shih-Min Huang. Complexity analysis of the
microcirculatory blood flow response following skin-surface local heating stimulation.
Proc. of the 6th World Congress on Biomechanics, 2010 (EI).
c2. Hsin Hsiu, Chia-Liang Hsu, Shih-Fan Hu. Using pulsatile photoplethysmographic
waveform index to discriminate the microcirculatory response under different
skin-surface temperature. Proc. of the 6th World Congress on Biomechanics, 2010 (EI).
c3. Chia-Liang Hsu, Hsin Hsiu, Tsung-Lin Wu. 光血管容積與血壓波形訊號之初步頻域
相關性研究, The preliminary research about the frequency correlation between PPG
and BPW. 中華民國九十八年度生物醫學工程科技研討會，2009。
c4. Shih-min Huang, Hsin Hsiu, Tse Lin Hsu. 脈波式微循環血流波形參數應用於ANG2
注入正常大白鼠效應之研究, Effects on Pulsatile waveform parameter of
microcirculatory boold flow by adminstating ANGⅡ in rat. 中華民國九十八年度生物
醫學工程科技研討會，2009。
c5. Hsin Hsiu, Wei-Chen Hsu, Chia-Liang Hsu. An alternative index for monitoring
microcirculatory blood flow: the beat-to-beat microcirculatory blood flow variability.
Proc. of the 2nd International Conference on Biomedical and Pharmaceutical
Engineering, 2009 (EI).
c6. Hsin Hsiu, Chia-Liang Hsu, Tsung-Lin Wu. A preliminary study on the correlation of
frequency components between finger PPG and radial arterial BP waveforms. Proc. of
the 2nd International Conference on Biomedical and Pharmaceutical Engineering,
2009 (EI).
c7. Hsin Hsiu, Wei-Chen Hsu, Chia-Liang Hsu, Shih-Min Huang, Ming-Yie Jan,
Wei-Kung Wang, Yuh-Ying Lin Wang. Spectral analysis on the microcirculatory laser
Doppler signal at the acupuncture point. Proc. of the 30th Annual Int. Conf. of the IEEE
EMBS, 2008 (EI).
c8. Hsin Hsiu, Wei-Chen Hsu, Chia Liang Hsu, Shih-Min Huang, Tse-Lin Hsu, Yuh-Ying
Lin Wang. Spectral analysis on the microcirculatory laser Doppler signal of the
acupuncture effect. Proc. of the 30th Annual Int. Conf. of the IEEE EMBS, 2008 (EI).
c9. 黃世銘，許昕，張書陵，賴志軍，王林玉英。不同力量的接觸力對於微循環效應
之研究。中華民國九十七年度生物醫學工程科技研討會，2008。
c10. 許家良、許昕、徐維偵、詹明宜、王林玉英：局部加熱對微循環血流效應之研究; Effect of Local heating on microcirculatory Blood Flow。中華民國九十七年度生物醫學工程科技研討會，2008。
c11. 黃世銘、許昕、王唯工：穴道微循環血流速之研究; Study on the microvascular blood velocity on acupoints。中華民國九十六年度生物醫學工程科技研討會，2007。
c12. Hsin Hsiu, Shih-Min Huang, Wei-Chen Hsu, Pin-Tsun Chao, Chia Liang Hsu,
Ming-Yie Jan, Wei-Kung Wang, Yuh-Ying Lin Wang. Study on the microcirculatory
blood velocity of acupoint monitored by laser Doppler signal. Proc. of the 29th Annual
Int. Conf. of the IEEE EMBS, 2007 (EI).
c13. Hsin Hsiu, Pin-Tsun Chao, Wen-Rei Chiang, Rei-Yan Hsu, Ming-Yie Jan, Tse-Lin Hsu,
Wei-Kung Wang, Yuh-Ying Lin Wang. Evaluation of stationarity of laser Doppler
signal in the pulse-based synchronized-averaging analysis. Proc. of the 29th Annual Int.
Conf. of the IEEE EMBS, 2007 (EI).
c14. H. Hsiu, P.T. Chao, W.C. Hsu, M. Y. Jan, Y. Y. Lin Wang, W. K. Wang. Comparing
the effects of internal pacing and external pacing on heart rate and blood pressure. Proc.
of Seoul 2006, World Congress on Medical Physics and Biomedical Engineering.
c15. 黃世銘、許昕、趙品尊、詹明宜、徐則林、王唯工：以脈波LDF 訊號觀察局部加熱對微循環血流之改變; Effects of local heating on the pulsailte Laser Doppler
Flowmetry waveform。中華民國九十五年度生物醫學工程科技研討會，2006。
c16. 周辰彥, 許昕, 鮑建國, 王聖宏, 李宗駿, 王唯工：生理溶液中pH量測之研究與生理變化應用之探討。中華民國九十四年度生物醫學工程科技研討會，2005。
c17. 許昕、鮑建國、周辰彥、李宗駿、王唯工：pH對水溶液高頻阻抗分配之研究與熱療應用之探討。中華民國九十三年度生物醫學工程科技研討會，2004。
c18. P.T. Chao, H. Hsiu, Jan MY, T.L. Hsu, W.K. Wang. A Study on the Wave Propagation Property – I: Comparison between long and short elastic tubes with radial resonance model. Proceeding of the IASTED International Conference on Biomedical Engineering, p105-109, Hawaii, USA, 2004.
c19. H. Hsiu, P. T. Chao, W.C. Hsu, M.Y. Jan, W.K. Wang. A study on the wave
propagation property. II: in arterial system of rats. Proceeding of the IASTED
International Conference on Biomedical Engineering, p110-113, Hawaii, USA, 2004.
c20. MY Jan, J.G. Bau, H. Hsiu, P.T. Chao, W.K. Wang. A Study on the Wave Propagation Property – III: with loop and microcirculation. Proceeding of the IASTED International Conference on Biomedical Engineering, p114-117, Hawaii, USA, 2004.
c21. Jan M Y, Hsiu H, Bau J G and Lin Wang Y Y. 2004 One important area gradient force
has been omitted in the Moens and Korteweg’s equation Proc. of the 26th Annual Int.
Conf. of the IEEE EMBS ,2004; 3681-3683.
c22. H. Hsiu, M.Y. Jan, A. Kou, Y.Y. Lin Wang, W.K. Wang. An apparatus to affect
hemodynamics by applying single-frequency mechanical stimuli. Proceeding of the
ISATED International Conference on Biomedical Engineering, Salzburg, Austria, 2003,
p132-134.
c23. H. Hsiu, M. Y. Jan, Y. Y. Lin Wang and W. K. Wang, Pace the heartbeat by
double-heartbeat-frequency sound wave. Proceedings of 24th Annual International
Conference of the IEEE Engineering in Medicine and Biology Society, Houston, USA,
2002.
c24. Y. Y. Lin Wang, M. Y. Jan, H. Hsiu and W. K. Wang. (2002) Hemodynamics with total energy. Proceeding of EMBS-BMES 2002, p.1240-1241, Houston, USA, 2002
c25. P. T. Chao, M. Y. Jan, H. Hsiu, W. K. Wang, Yuh-Ying Lin Wang, (2002)
"COMPARISON OF RENAL CORTICAL FLOW BETWEEN SHR AND WKY
BASED ON WAVELET TRANSFORM". Proceedings of International Federation for
Medical and Biological Engineering EMBEC 02’ Vienna, Austria, 2002 , vol 3,
p502-p503.
c26. Kuo, Y.C., T.Y. Chiu, J.G. Bau, P.T. Chao, M.Y. Jan, H. Hsiu and W.K. Wang. Raised harmonic variations of radial arterial pulse before death of cancer patients. Proceedings of the 4th International Workshop on Biosignal Interpretation (BSI2002), 2002, pp. 267– 269.
c27. Hsiu, H., Jan, M. Y., Wang Lin, Y. Y., Wang & W. K. Applying the resonance
equation to the blood pressure waveform variation in aorta bending and renal ligation.
Proc. of Istanbul 2001, World Congress on Medical Physics and Biomedical
Engineering, p73.
c28. 許昕、詹明宜、王唯工、王林玉英：心率二倍頻聲波對循環系統運作之影響。中華民國九十年度生物醫學工程科技研討會，2001。
c29. Hsiu, H., Jan, M.Y., Wang Lin, Y. Y., Wang, W. K. & Hsu, T. L. Effects of pulling
aorta on blood pressure and its implication in hypertension. Proc. of Chicago 2000,
World Congress on Medical Physics and Biomedical Engineering.
c30. Bau, J. G., Wang, G. C., Chiang, Y., Hsu, T. L., Hsiu, H., Jan, M. Y. & Wang, W. K. A micro-invasive interstitial fluid analyzer. Conference: Chicago 2000, World Congress
on Medical Physics and Biomedical Engineering.
c31. Huang CY, Jan MY, Hsiu H, Yu GL, Wang Lin YY, Wang WK. (2000) The
microvascular flux wave is coherent with the aortic blood pressure wave. Conference:
Chicago, World Congress on Medical Physics and Biomedical Engineering.
c32. Wang, W. K., Wang, G. C., Hsiu, H. & Bau, J. G. The relationship between the
Bio-independence of the body and the blood circulation. Med. Biol. Eng. & Com. 37,
suppl. 2: p110-111, 1999.
c33. Hsiu, H., Jan, M. Y. & Wang, W. K. Transmission efficiency of the aortic bifurcation in
rats. Proc. of the 20th annual international conference of the IEEE engineering in Med.
Biol. Society vol. 20, No. 1: p399-400, 1998.
c34. Wang, W. K., Jan, M. Y., Hsiu, H. & Huang, C. Y. Two phases of the pulsatile
microcirculation with relation to hypertension. Biorheology 36, No. 1: p175, 1998.
c35. Jan, M. Y., Hsiu. H., Wang Lin, Y. Y. & Wang, W. K. A modified fast laser Doppler
flowmetry measure the pulsatile microcirculation in rats. Proc. of the 20th annual
international conference of the IEEE engineering in Med. Biol. Society vol. 20, No. 1:
415-416, 1998.
c36. Bau, J. G., Hsiu, H., Chiang, Y., Wang Lin, Y. Y. & Wang, W. K. Different response
from different electrodes- an application in composition analyzing of solution. Proc. of
the 20th annual international conference of the IEEE engineering in Med. Biol. Society
vol. 20, No. 1: p795, 1998.
c37. Wang, W. K., Wang Lin, Y. Y., Lai, W. C., Hsiu, H. & Jan, M. Y. The length effect of
the fundamental resonance frequency in the arterial models with radial dilatation. Med.
Biol. Eng. Comput. 35, suppl. 1: p223, 1997.

國科會計畫

• 具pH 導向聚焦特性微小型癌症熱療電極系統之開發(92/8-93/7, 國科會計畫,
  NSC92-2218-E- 155-004, 經費：509700 元，主持人)
• 血壓波形頻域分析與腎臟微循環血流量關連性之探討 (93/8-94/7, 國科會計畫，
  NSC93-2213- E-155-023, 經費：611800 元，主持人)
• 紅外光血液容積量測應用於血壓波形量測之循環生理因素研究 (95/8-96/7, 國科會
  計畫，95-2221-E-155-002, 經費：616000 元，主持人)
• 非侵入脈動式微循環生理指標狀態評估指標之開發 (96/8-98/7, 國科會二年期計畫，96-2221-E-155-001-MY2, 經費：1202000 元，主持人)
• 元智大學通訊中心頂尖大學計畫之汽車電子計畫。子計畫名稱：整合生醫訊號量測分析於汽車電子，95, 96 年度，子計畫主持人。
• 結合診斷與治療之整合性脈波式末端微循環血流量監控與改善技術之研究
  (98/8-99/7, 國科會計畫，98-2221-E-155-007-, 經費：552000 元，主持人)
• 微循環血流變異度之研究(99/8-101/7, 國科會計畫，99-2221-E-155-002-MY2, 經費：1,189,0000 元，主持人)

 重要研究概述

• 92/8-93/7  具pH導向聚焦特性微小型癌症熱療電極系統之開發
• 93/8-94/7 血壓波形頻域分析與腎臟微循環血流量關連性之探討
• 95/8-96/7 紅外光血液容積量測應用於血壓波形量測之循環生理因素研究
• 96/6-98/7 非侵入脈動式微循環生理指標狀態評估指標之開發
• 95/7-96/9 整合生醫訊號量測分析於汽車電子
• 98/8-99/7 結合診斷與治療之整合性脈波式末端微循環血流量監控與改善技術之研究
• 99/8-101/7 微循環血流變異度之研究