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蔡協致

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應用科技研究所
 
學經歷:
  學歷:
國立清華大學化學工程所博士 2007.07

經歷:
國立清華大學生醫工程中心 博士後研究 2007.08-2008.08
東京大學醫學院研究科 訪問研究員 2008.09-2009.08
國立清華大學化學工程所 博士後研究 2009.09-2009.12


 
專業技術
  功能性高分子,奈米藥物載體,高分子納米複合材料,光電高分子
   
專利介紹
  胃腸道植入物及其部署方法  
肥胖及其衍生的血糖控制問題為近幾年來所產生新醫療問題,隨著人們飲食習慣的變化,以至於肥胖成為現今社會......
 

研究計畫
 

教授課程

化學,奈米分析技術,高分子奈米複合材料,高分子奈米結構.

Refereed Papers

1. H. C. Tsai, W. J. Kuo, and G. H. Hsiue, “Highly Thermal Stability Main-chain Nonlinear Optical Polyimide Based on Two-Dimensional Carbazole Chromophores. Macromol. Rap. Commun., 2005, 26, 986-991.(SCI impact factor:4.263)

2. H. C. Tsai, I. C. Yu, P. H. Chang, D.C. Yu and G. H. Hsiue, “Novel π-Electron Extension System via Chromophores Self-polymerization to Enhance the NLO Efficiency”, Macromol. Rap. Commun., 2007, 28, 334-339. (SCI impact factor:4.263) 3. P.-H. Chang,† H.-C. Tsai,† Y.-R. Chen, J.-Y. Chen, and G.-H. Hsiue, ”Thermal Stability and Structural Characterization of Organic/ Inorganic Hybrid Nonlinear Optical Material Containing a Two-Dimensional Chromophore”, Langmuir 2008, 24, 11921-11927(equal first author) (SCI impact factor:4.363)

 4. C.-L. Lo,† S.-J. Lin, † H.-C. Tsai, † W.-H. Chan, C.-H. Tsai, C.-H. D. Cheng and G. H. Hsiue, “Mixed Micelles Formed by Temperature- and Concentration-Sensitive Diblock Copolymers for Improving Stability of Drug Carriers”, Biomaterials, 2009, 30, 3961-3970. (equal first author) (SCI impact factor:7.365)

5. P.-H. Chang1, J.-Y. Chen , H.-C. Tsai, Ging-Ho Hsiue, “Molecular design of nonlinear optical polymer based on DCM to enhance the NLO efficiency and thermal stability”, Journal of Polymer Science Part A: Polymer chemistry, 2009, 47, 4937-4949 (SCI impact factor:3.971)

 6. H.-C. Tsai, W.-H. Chang, C.-L. Lo, C.-H. Tsai, C.-H. Chang, T.-W. Ou, T.-C. Y., G.-H. Hsiue, “Graft and Diblock Copolymer Multifunctional Micelles for Cancer Chemotherapy and Imaging”, Biomaterial, 2010, 31, 2293-2301. (SCI impact factor: 7.365)

7. Y.-C. Chiu, H.-C. Tsai, I.-C. Chou, W.-N. Lin, S.-Y. Yang, H.-W. Tien, C.-C. M. Ma, “Preparation Intermolecular Motion and Thermal Properties of Thiodiphenyl Epoxy”, J. Appl. Polym. Sci., 2010, 118, 2116-2125. (SCI impact factor: 1.203)

8. Y.-C. Chiu, H.-C. Tsai, I.-C. Chou, S.-M. Li, C.-C. M. Ma, “Intermolecular Force and Thermal Properties of Sulfonyl Epoxyl Blends Cured with DGEBA Epoxy”, J. Appl. Polym. Sci., 2010, 118, 2165-2175. (SCI impact factor: 1.203)

 9. Y.-C. Chiu, I.-C. Chou, H.-C. Tsai, L. Riang, C.-C. M. Ma, “Morphology, Thermal and Mechanical Properties of the Polyhedral Oligomeric Silses
quinoxane (POSS) side chain Epoxyl Hybrid Materials”, J. Appl. Polym. Sci., 2010,118, 3723-3732. (SCI impact factor: 1.203)

10. P.-L. Lu, Y.-C. Chen, T.-W. Ou; H.-H. Chen, H.-C. Tsai, C.-J. Wen, C. L. Lo, S. P. Wey, K. J. Lin, T. C. Yen, G. H. Hsiue, ”Multifunctional Hollow Nanoparticles based on Graft-Diblock copolymer for Doxorubicin Delivery”, Biomaterials, 2010, 32, 2213-2221. (SCI impact factor: 7.365)

11. S.-Y. Lin, W.-H. Hsu, J.-M. Lo, H.-C. Tsai, G.-H. Hsiue, “Novel Geometry Type of Nanocarriers Mitigated the Phagocytosis for Drug Delivery”, Journal of Controlled Release, 2011, accepted. (SCI impact factor: 5.945)

12. H.-C. Tsai*, C.-H. Chang, Y.-C. Chiu, S.-Y. Lin, C.-P. Lin, G.-H. Hsiue*, “In Vitro Evaluation of Hexagonal Polymeric Micelles in Macrophage Phagocytosis”, Macromol. Rap. Commun., 2011, accepted, (equal corresponding author). (SCI impact factor: 4.263)

13. Y.-C. Chiu, H.-C. Tsai*, T. Imae, “Thermal Degradation Analysis of the isocyanate polyhedral oligomeric silsequioxanes (POSS)/sulfone epoxy nanocomposite”, 2011, J. Appl. Polym. Sci. accepted. (SCI impact factor: 1.203)

 會議論文

1. H. C. Tsai, W. J. Kuo, and G. H. Hsiue, “Thermal and temporal stability two dimensional main-chain NLO polymers”, 2003 MMC-10, Poster, May. 18-23, Moscow.

 2. K. T. Li, and H. C. Tsai, "Chemical vapor deposition for preparing Ti/SiO2 epoxidation catalysts: EBHP as the oxidant", proceeding of the 3rd Conference of the Indo-Pacific Catalysis Association, OR-A-16, 2003, Nov. Indo-Pacific Catalysis Association, Taipei.

3. H. C. Tsai, W. J. Kuo, R. J. Jang and G. H. Hsiue,” Λ-shaped NLO polyurethane based on 2-D chromophore”, 2003 26th polymer symposium, AP-1-26, Poster, Jan. 17-18, Tainan.

4. D. C. Yu, H.C. Tsai, and G. H. Hsiue, “Nonlinear Optical Properties of PVK and PCz Guest Host System” 2006 Annual Meeting of the Polymer society, CP-A-05, Poster, Jan. 14-15, Kaoshiung.

 5. H. C. Tsai, I. C. Yu, and G. H. Hsiue, “Nonlinear optical properties and photophysic 2,7 PolyCarbazole Main Chain system ” 2006 Annual Meeting of the Polymer society, CP-B-35 Poster, Jan. 14-15, Kaoshiung.
6. H. C. Tsai, I. C. Yu, and G. H. Hsiue, “Integrating π-Electron of conjugated polymer and chromophores nonlinear optical polymers”, 2006 MRS Fall Meeting, Poster, Nov. 25-29, Boston.

7. H. C. Tsai, H. H.Chen, C. L. Lo, and G. H. Hsiue, “Novel pH trigger Mixed Micelles with Rapid on-off Drug Release Behavior”, 2008 Annual Meeting of the Polymer society, Poster, Jan 18-19, Hsinchu.

 8. H. C. Tsai, C. L. Lo, K. M. Lin, and G. H. Hsiue, “Environmental-Sensitive Micelles Based on Poly(2-ethyl-2-oxazoline)-b-Poly (L-lactide) Diblock Copolymer for Application in Drug Delivery”, IUPAC 2008 Macro, Poster, IUPAC 2008 Macro, June 29-July 4, Taipei.

9. G.H. Hsiue, C. L. Lo, H. C. Tsai,” Multifunctional Micelles from Graft and Diblock Copolymers for Cancer Diagnosis and Cancer Therapy “,2009 KAIST-TIT joint symposium, Oral, Naogoya, Oct 22-24, Japan.

 10. H. C. Tsai, W. H. Chang, C. L. Lo, T. C. Yen, G. H. Hsiue, “Doxorubicin Loaded Multifunctional Mixed Micelles: Tumor Diagnosis, Targeting and Antitumor Efficiency against HeLa Cells, NanoEurope 2009, Poster, Rapperswil, Nov. 25-26, Swiss.

11. H. C. Tsai, Y. C. Chen, C. L. Lo, and G.H. Hsiue, “Multifunctional micelles for Cancer Targeting, diagnosis and therapy ” The Biomedical Engineering Society 2009 Annual Symposium, Dec 11-12, Taipei.

12. H. C. Tsai, and T. Imae, “Two-Photon Emission Difluorobron Dye for Cell Imaging: Cell Uptake of PAMAM-denron with HeLa Cells”, 2011 Annual Meeting of the Polymer society, Poster, Jan 21-22, Taichung.

 13. S.-Y. Lin, W.-H. Hsu, J.-M. Lo, H.-C. Tsai, G.-H. Hsiue, “The Impact of Different Geometric Nanocarriers on the Immune Avoidance”, International Conference on Materials for Advanced Technologies 2011, ICMAT11-A-5102, Poster, June 26- July 1, Singapore.

14. H.-C. Tsai, T. Imae, G. Calderó, C. Solans, “Investigation of Dendron materials and HeLa cell membrane interaction by two photon confocal microscopy”, The 3rd International Syposium on Surface and Interface of Biomaterials 2011, SIB-0013, Poster, July 12-15, Sapporo.

15. H.-M. Chang, H.-C. Tsai, T. Imae, “To Evaluate the Biodegradable Polylactic acid Film as Gastro-Jejunal Tube for Duodenal Exclusion” The 3rd International Syposium on Surface and Interface of Biomaterials 2011, SIB-047, Poster, July 12-15, Sapporo.