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Synthesis of biocompatible confeito-like nanoparticles and their application for medical therapy
 
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技術名稱
Technology
Synthesis of biocompatible confeito-like nanoparticles and their application for medical therapy
發明人
Inventor
氏原真樹, 今榮東洋子,
所有權人
Asignee
國立臺灣科技大學

專利國家
Country
申請號
Application No.
專利號
Patent No.
中心案號
Serial No.
中華民國 100147776 I459965 1000018TW0
美國 13/333,868 US9162287 1000018US0
 
點閱數:222
技術摘要:
Using hydroxyl peroxide as a reducing agent at an alkaline condition, a series of gold nanoparticles with confeito-like shapes can be obtained in the presence of a biocompatible protector but without toxic byproducts. The obtained confeito-like nanoparticles (C-AuNPs) could be safely taken to living cancer cells by aid of folic acid. Thus the C-AuNP can be used for biomedical applications.
Meanwhile, cancer cells (HeLa cells) are killed by a short-time irradiation of a near-infrared laser (at wavelength of 785 nm) when the C-AuNP exists in the cells. This carcinolysis is likely due to the strong plasmon absorption of the C-AuNP at the near-infrared region.
On the other hand, the cancer cells including the C-AuNP can survive for the irradiation at the wavelength of 633 nm, which is near the plasmon absorption band of the C-AuNP. In this condition, the C-AuNP is quickly converted to small spherical nanoparticles, and the resulted small nanoparticles are less photoactive than the C-AuNP. This conversion suggests that the C-AuNP is useful for the controlled drug-releasing devises.


 
   




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