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技術名稱 Technology
發明人 Inventor
氏原真樹, 今榮東洋子,
所有權人 Asignee 國立臺灣科技大學

專利國家 Country 申請號 Application No. 專利號 Patent No. 中心案號 Serial No.
美國 13/333,868 US9162287B2 1000018US0
  點閱數:888

技術摘要:
Using hydroxyl peroxide as a reducing agent at an alkaline condition, a series of gold nanoparticles with confeito-like shapes can be obtained in the presence of a biocompatible protector but without toxic byproducts. The obtained confeito-like nanoparticles (C-AuNPs) could be safely taken to living cancer cells by aid of folic acid. Thus the C-AuNP can be used for biomedical applications.
Meanwhile, cancer cells (HeLa cells) are killed by a short-time irradiation of a near-infrared laser (at wavelength of 785 nm) when the C-AuNP exists in the cells. This carcinolysis is likely due to the strong plasmon absorption of the C-AuNP at the near-infrared region.
On the other hand, the cancer cells including the C-AuNP can survive for the irradiation at the wavelength of 633 nm, which is near the plasmon absorption band of the C-AuNP. In this condition, the C-AuNP is quickly converted to small spherical nanoparticles, and the resulted small nanoparticles are less photoactive than the C-AuNP. This conversion suggests that the C-AuNP is useful for the controlled drug-releasing devises.

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